What triggers polyphagia in diabetes?

What triggers polyphagia in diabetes?

• A. Increased appetite due to insulin
• B. Cell starvation due to lack of glucose uptake
• C. Decreased appetite due to high glucose
• D. Hunger due to weight loss

Answer: (B)

Cellular energy starvation due to lack of glucose uptake triggers polyphagia in diabetes. When insulin is deficient or signaling is impaired, glucose cannot enter most body cells effectively, especially muscle and fat tissue. The bloodstream may be full of glucose, but the cells themselves are starved for fuel, and the brain responds by increasing hunger to obtain more energy. This hunger is a response to intracellular scarcity, not a direct effect of insulin increasing appetite. High blood glucose doesn’t suppress appetite, and weight loss is a downstream consequence of ongoing catabolism, not the immediate trigger of polyphagia.

Cellular energy starvation due to lack of glucose uptake triggers polyphagia in diabetes. When insulin is deficient or signaling is impaired, glucose cannot enter most body cells effectively, especially muscle and fat tissue. The bloodstream may be full of glucose, but the cells themselves are starved for fuel, and the brain responds by increasing hunger to obtain more energy. This hunger is a response to intracellular scarcity, not a direct effect of insulin increasing appetite. High blood glucose doesn’t suppress appetite, and weight loss is a downstream consequence of ongoing catabolism, not the immediate trigger of polyphagia.